I never heard him say that..who did he say that to.I suspect that in real life Reynold would not use that phrase (last f***able) to a mixed sex, mixed age audience, but with his peer group of overgrown frat boys. I suspect he was being interviewed by another male of around his age, with a male cameraman, and "forgot" that the audience viewing what he said would be very different from the "audience" to whom he was saying it. Not that it makes it better to say it behind women's backs, just more "normal". Sadly there are a lot of men like Reynold--acceptably polite to your face, crude and misogynistic behind your back.
And Reynold is currently from San Francisco, about the most politically correct city on the planet, but even there apparently Reynold has a peer group.