Winamp isn't anything like what it used to be, Musicmatch Jukebox is bloated, and I think the old Sonique is simply gone now. There's something about iTunes that makes me vaguely nauseous.
I can't believe I'd ever catch myself saying this, but lately, I've found myself using Windows Media Player (version 10) more and more often. I don't buy music from MSN Music, and the interface is often unfriendly and non-intuitive, but after using most of the other major players, I find myself returning to WMP.
What about all you music-philes? Any preferences?