I'm pretty much all left handed. The only thing I do right handed is golf. (which I do very badly)
My dad was left handed but had it beaten out of him in public school so he does most things right handed and my sister is left handed but golfs right.
My hand writing is a sight. I tend to almost lay down to get get the curve right. I don't even bother with power tools. I noticed in driving, I would prefer the radio to be on my left side so I can mess with the buttons easier.