I've been a fan of Amazon since the site started. My bookstore choices are (aside from specialty ones, such as religious shops and one that focuses on local history and writers) are Books-a-Million or the other Books-a-Million and Barnes & Noble or the other Barnes & Nobel. If I can order from my house, have it delivered to my door, and escape gaggles of free-range teens slugging back coffee, clearly I'm sticking with Amazon. Growing up we had a chain bookstore (Little Professor) really close to the house and, though it was a chain, it was fun to go in since we got to know the lady who owned it and it was very neighborhood-y and almost indie feeling. If I had a smaller store like that, I'd probably go, but I don't see that as economically viable in these times.
That being said 95% of what I order from Amazon is not books. The last thing I ordered was a new dog leash since it was about half what Petsmart charges. (And, for the record, the last indie pet store that was around here closed two years ago. The closing was a good thing--it was terribly depressing and the animals always looked sick.)