I'm reading Middlesex, and so far love it. I have a friend who is an xy woman, because she has AIS syndrome, so she was born a girl, and then when puberty hit, they found what they though was a hernia, but was actually two undescended testicles. Her parents hid the truth from her for years, and she finally discovered it on the internet and confronted her doctor, who also hid it from her. So really, she is a man, but identify's as an xy woman. It's a different syndrome than the main character in Middle Sex though, but similar.