I don't think "flustrated" is regional. I've heard it quite a few times. In fact, one of the ladies on Fear Factor said it just within the last week or two. (Can you tell it bugs me too?)
When I was a little kid my mom used to say "libary" instead of "library". I used to correct her so often that she finally developed a hang-up about using the word and would deeply overemphasize the first "r" sound.